Posted on October 24, 2011 Updated on October 28, 2011
This entry was posted in Positioning- Lower Limmb.
I truly appreciate this article.Thanks Again. Keep writing.
financial advice seminars
Really appreciate you sharing this blog.Thanks Again. Much obliged.
Contractor Advertising Experts – CONTRACTORS – Double your website traffic and never pay for advertising again! ContractorAdvertisingExperts.com
This is one awesome article. Really Great.
web design miami
I really liked your blog. Want more.
Automotive Advertising – Lotlinx is the best automotive advertising available. List your vehicles on 200 auto sites and draw 250% more car shoppers than Google Adwords for 65% less
Great, thanks for sharing this blog post.Much thanks again. Cool.
concert ear plug – DownBeats is a cool brand of high fidelity hearing protection for concerts.
wow, awesome blog post.Thanks Again. Great.
Great, thanks for sharing this blog.Much thanks again. Really Cool.
Enjoyed every bit of your article post. Cool.
high blood pressure symptoms
Im thankful for the post.Really thank you! Fantastic.
I value the article.Really thank you! Keep writing.
tick bite signs
I truly appreciate this blog.Thanks Again. Really Cool.
Kidney Failure Symptoms
Thanks-a-mundo for the article.Really looking forward to read more. Great.
Thanks a lot for the post.Thanks Again. Awesome.
شركة تنظيف فلل بالرياض
I truly appreciate this blog post.Much thanks again. Want more.
ШґШ±ЩѓШ© Щ†Щ‚Щ„ Ш§Ш«Ш§Ш« ШЁШ§Щ„Ш±ЩЉШ§Ш¶
I cannot thank you enough for the blog post.Really thank you! Really Cool.
free telugu The Expendables 3 download
Major thanks for the blog post.Thanks Again. Really Cool.
High & Low brow
Thanks for sharing, this is a fantastic blog post.Really thank you! Really Cool.
tenerife jet ski safari
Hey, thanks for the blog.Much thanks again. Fantastic.
Malaysia interior designer
Appreciate you sharing, great blog.Really thank you! Great.
2D Animation Design
Thanks-a-mundo for the post.Thanks Again. Cool.
Cheats Tips Hacking
Thanks for sharing, this is a fantastic blog article.Really looking forward to read more. Awesome.
investing overseas – Investor Network a premium source for Investors and investments, providing news and insight into the UK’s financial markets to private investors
Thanks for the blog article.Much thanks again. Will read on…
I cannot thank you enough for the blog post.Thanks Again. Awesome.
Ephedra diet pills
Really enjoyed this blog post.Really thank you! Much obliged.
alternative investing – The Investment Network advertises Investment Opportunities across the world ranging from Alternative, Financial, Regulated and Forex Trading Investments
Great post.Really thank you! Much obliged.
Elliott Broidy – Broidy Capital Management is an investment firm based in Los Angeles, California. Broidy Capital Management is run by Mr Elliott Broidy who serves as CEO and Chairman. The firm was founded in 1991. We participate in public and private capital markets and invest in a broad range of sectors in the US and overseas. The main sectors we focus on are; service, technology, infrastructure, energy, real estate, financial services, mining and logistics.
Thank you ever so for you blog article.Thanks Again. Will read on…
best 7 inch tablet
Extraordinarily educative thanks, I believe your trusty readers could want even more information similar to this carry on the good effort.
Islet Cell Liver Metastases: Assessment of Volumetric Early Response with Functional MR Imaging after Transarterial Chemoembolization
Zhen Li, MD, PhD,
Susanne Bonekamp, DVM, PhD,
Vivek Gowdra Halappa, MD,
Celia Pamela Corona-Villalobos, MD, PhD,
Timothy Pawlik, MD,
Nik Bhagat, MD,
Diane Reyes, BS,
Hong Lai, PhD,
Jean F. Geschwind, MD and
Ihab R. Kamel, MD, PhD
+ Author Affiliations
From the Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Z.L.); and Russell H. Morgan Department of Radiology and Radiological Science (S.B., V.G.H., C.P.C., N.B., D.R., H.L., J.F.G., I.R.K.) and Department of Surgery (T.P.), the Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC 4240, Baltimore, MD 21287.
Address correspondence to
I.R.K. (e-mail: firstname.lastname@example.org).
Author contributions: Guarantors of integrity of entire study, Z.L., C.P.C., T.P., I.R.K.; study concepts/study design or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for important intellectual content, all authors; approval of final version of submitted manuscript, all authors; literature research, Z.L., V.G.H., C.P.C., H.L., I.R.K.; clinical studies, Z.L., S.B., V.G.H., J.F.G., I.R.K.; statistical analysis, Z.L., S.B., C.P.C., H.L., J.F.G., I.R.K.; and manuscript editing, all authors
Purpose: To assess early response to transarterial chemoembolization by using volumetric functional magnetic resonance (MR) imaging in patients with islet cell liver metastases (ICLMs).
Materials and Methods: This retrospective institutional review board–approved HIPAA-compliant study included 215 ICLMs in 26 patients (15 men, 11 women; mean age, 59.7 years; age range, 37–79 years). Volumetric measurements were performed by an experienced radiologist on diffusion-weighted and contrast material–enhanced MR images at baseline and 1-month follow-up. Measurements included mean change (three-dimensional [3D] mean apparent diffusion coefficient [ADC], 3D mean enhancement) and percentage of tumor with change above a predetermined threshold (3D threshold ADC, 3D threshold enhancement). Response by volumetric measurements at 1-month follow-up was compared with Response Evaluation Criteria in Solid Tumors (RECIST) at 6-month follow-up. Lesions that had complete or partial response were considered responders, while those with stable or progressive disease were considered nonresponders. Statistical analysis included the t test, receiver operating characteristic (ROC) curve analysis, and logistic regression analysis.
Results: RECIST criteria at 6-month follow-up indicated 78 (36.3%) lesions responded, while 137 (63.7%) did not. The increase in 3D mean ADC was significantly higher in responders than in nonresponders (median, 26.2% vs 10.9%; P < .001). The 3D threshold ADC was 71.1% in responders and 47.6% in nonresponders (P < .001). Decrease in 3D mean arterial enhancement (AE) was significantly higher in responders than in nonresponders (median, 40.5% vs 18.0%; P < .001). Decrease in 3D mean venous enhancement (VE) was significantly higher in responders than in nonresponders (median, 28.0% vs 10.0%; P < .001). The 3D threshold VE and 3D threshold AE did not differ between responders and nonresponders. In unadjusted logistic regression analyses, 3D mean ADC and 3D threshold ADC had the highest odds ratio (1.02 and 1.03, respectively) and the largest area under the ROC curve (0.698 and 0.695, respectively).
Conclusion: Volumetric functional MR imaging could be used to predict early response of hepatic ICLMs to therapy and to distinguish between responders and nonresponders.
© RSNA, 2012
Received October 10, 2011; revision requested November 14; revision received January 9, 2012; accepted January 19; final version accepted February 7.
S.B. and I.R.K. supported by Bracco Diagnostics, Bayer Healthcare, and Siemens Medical Solutions.
Abbreviations:ADC = apparent diffusion coefficientAE = arterial enhancementDW = diffusion weightedICLM = islet cell liver metastasisICT = islet cell tumorIQR = interquartile rangePD = progressive diseasePR = partial responseRECIST = Response Evaluation Criteria in Solid TumorsSD = stable diseaseTACE = transarterial chemoembolizationVE = venous enhancement
Prostate Cancer: Feasibility and Preliminary Experience of a Diffusional Kurtosis Model for Detection and Assessment of Aggressiveness of Peripheral Zone Cancer
Andrew B. Rosenkrantz, MD,
Eric E. Sigmund, PhD,
Glyn Johnson, PhD,
James S. Babb, PhD,
Thais C. Mussi, MD1,
Jonathan Melamed, MD,
Samir S. Taneja, MD,
Vivian S. Lee, MD, PhD, MBA2 and
Jens H. Jensen, PhD3
From the Department of Radiology (A.B.R., E.E.S., G.J., J.S.B., T.C.M., V.S.L., J.H.J.), Department of Pathology (J.M.), and Division of Urologic Oncology, Department of Urology (S.S.T.), New York University Langone Medical Center, 550 First Ave, TCH-HW202, New York, NY 10016.
Address correspondence to
A.B.R. (e-mail: Andrew.Rosenkrantz@nyumc.org).
Author contributions: Guarantor of integrity of entire study, A.B.R.; study concepts/study design or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for important intellectual content, all authors; manuscript final version approval, all authors; literature research, A.B.R., E.E.S., J.H.J.; clinical studies, A.B.R., E.E.S., G.J., T.C.M., J.M., S.S.T., J.H.J.; statistical analysis, J.S.B.; and manuscript editing, A.B.R., E.E.S., G.J., J.S.B., T.C.M., S.S.T., V.S.L., J.H.J.
Purpose: To assess the feasibility of diffusional kurtosis (DK) imaging for distinguishing benign from malignant regions, as well as low- from high-grade malignant regions, within the peripheral zone (PZ) of the prostate in comparison with standard diffusion-weighted (DW) imaging.
Materials and Methods: The institutional review board approved this retrospective HIPAA-compliant study and waived informed consent. Forty-seven patients with prostate cancer underwent 3-T magnetic resonance imaging by using a pelvic phased-array coil and DW imaging (maximum b value, 2000 sec/mm2). Parametric maps were obtained for apparent diffusion coefficient (ADC); the metric DK (K), which represents non-Gaussian diffusion behavior; and corrected diffusion (D) that accounts for this non-Gaussianity. Two radiologists reviewed these maps and measured ADC, D, and K in sextants positive for cancer at biopsy. Data were analyzed by using mixed-model analysis of variance and receiver operating characteristic curves.
Results: Seventy sextants exhibited a Gleason score of 6; 51 exhibited a Gleason score of 7 or 8. K was significantly greater in cancerous sextants than in benign PZ (0.96 ± 0.24 vs 0.57 ± 0.07, P < .001), as well as in cancerous sextants with higher rather than lower Gleason score (1.05 ± 0.26 vs 0.89 ± 0.20, P < .001). K showed significantly greater sensitivity for differentiating cancerous sextants from benign PZ than ADC or D (93.3% vs 78.5% and 83.5%, respectively; P .99). K exhibited significantly greater sensitivity for differentiating sextants with low- and high-grade cancer than ADC or D (68.6% vs 51.0% and 49.0%, respectively; P ≤ .004) but with decreased specificity (70.0% vs 81.4% and 82.9%, respectively; P ≤ .023). K had significantly greater area under the curve for differentiating sextants with low- and high-grade cancer than ADC (0.70 vs 0.62, P = .010). Relative contrast between cancerous sextants and benign PZ was significantly greater for D or K than ADC (0.25 ± 0.14 and 0.24 ± 0.13, respectively, vs 0.18 ± 0.10; P < .001).
Conclusion: Preliminary findings suggest increased value for DK imaging compared with standard DW imaging in prostate cancer assessment.
Fill in your details below or click an icon to log in:
You are commenting using your WordPress.com account. ( Log Out / Change )
You are commenting using your Twitter account. ( Log Out / Change )
You are commenting using your Facebook account. ( Log Out / Change )
You are commenting using your Google+ account. ( Log Out / Change )
Connecting to %s
Notify me of new comments via email.
Notify me of new posts via email.